I have to share this with you. It's the worst pickup line I have ever heard and the greatest comeback. Some back-story, this guy, Annoying Man, was hitting on every woman in the bar. EVERYONE was starting to really hate this guy. He was nicely defeated however:

Annoying Man: Hey baby, you would look really great sitting on my face!!

Witty Woman: RRREEEAAAALLLLYYYY!!!! Is that because your nose is bigger than your penis?


Needless to say, Annoying Man left the bar and Witty Woman drank for free the rest of the night.